Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish.
Identifieur interne : 000753 ( Main/Exploration ); précédent : 000752; suivant : 000754Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish.
Auteurs : Arianna Servili [France] ; Yann Le Page [France] ; Jérôme Leprince [France] ; Alain Caraty [France] ; Sebastian Escobar [Espagne] ; Ishwar S. Parhar [Malaisie] ; Jae Yong Seong [Malaisie] ; Hubert Vaudry [France] ; Olivier Kah [France]Source :
- Endocrinology [ 0013-7227 ] ; 2011-04.
Abstract
Kisspeptins are new actors in the neuroendocrine regulation of reproduction. In vertebrates, the number of kiss genes varies from none to three. Zebrafish have two kiss genes, kiss1 and kiss2, and two kiss receptors (GPR54), kiss1r and kiss2r. To provide detailed information on the organization of the kiss systems in zebrafish, antibodies were raised against the C terminus of zebrafish preproKiss1 and preproKiss2. Immunohistochemistry fully confirmed in situ hybridization data, showing that kiss1-expressing neurons are only located in the habenular nucleus, while kiss2-expressing neurons are found in the dorsal and ventral hypothalamus. Kiss1-expressing cells project only to the interpeduncular and raphe nuclei and strongly expressed the kiss1r receptor. In contrast, kiss2-expressing cells are mostly present in the dorsal and ventral hypothalamus and project widely into the subpallium, the preoptic area, the thalamus, the ventral and caudal hypothalamus, and the mesencephalon. All these regions strongly expressed the kiss2r messengers. Kiss2 fibers profusely innervate the ventral forebrain and notably made close apposition with GnRH3 neurons. Estrogen treatment of juvenile fish with estradiol causes increase in kiss2 and kiss2r expression. In the pituitary gland, no proKiss2- positive fibers were detected, while positive cells were observed in the pars intermedia. In addition to proposing a successful strategy to develop antibodies to kisspeptins, these data indicate that the kiss2 systems of zebrafish are implicated in reproductive events, while the kiss1 gene would play other functions that remain to be established.
Url:
DOI: 10.1210/en.2010-0948
Affiliations:
- Espagne, France, Malaisie
- Centre-Val de Loire, Haute-Normandie, Région Bretagne, Région Centre, Région Normandie
- Le Havre, Rennes, Rouen, Tours
- Centre Val de Loire Université, Université François-Rabelais de Tours, Université de Rennes 1, Université de Rouen, Université du Havre, Université européenne de Bretagne
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000247
- to stream Hal, to step Curation: 000247
- to stream Hal, to step Checkpoint: 000378
- to stream Main, to step Merge: 000758
- to stream Main, to step Curation: 000753
Le document en format XML
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CS 46510 - 35065 Rennes cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-rennes1.fr/</ref> </desc></org></tutelle><tutelle active="#struct-300972" type="direct"><org type="institution" xml:id="struct-300972" status="VALID"> <orgName>IFR140</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle name="UMR6026" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rennes</settlement><region type="region" nuts="2">Région Bretagne</region></placeName><orgName type="university">Université de Rennes 1</orgName><orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName></affiliation></author><author><name sortKey="Leprince, Jerome" sort="Leprince, Jerome" uniqKey="Leprince J" first="Jérôme" last="Leprince">Jérôme Leprince</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1752" status="OLD"> <orgName>IFR multidisciplinaire sur les peptides</orgName> <orgName type="acronym">IMP</orgName> <desc> <address> <addrLine>Place Emile Blondel 76821 Mont Saint Aignan cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-rouen.fr/ifrmp23</ref> </desc> <listRelation> <relation active="#struct-300147" type="direct"></relation> <relation active="#struct-300317" type="direct"></relation> <relation active="#struct-300318" type="direct"></relation> <relation active="#struct-301860" type="direct"></relation> <relation name="IFR23" active="#struct-303623" type="direct"></relation> <relation name="IFR23" active="#struct-441569" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-300147" type="direct"><org type="institution" xml:id="struct-300147" status="VALID"><orgName>CHU Rouen</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300317" type="direct"><org type="institution" xml:id="struct-300317" status="VALID"><orgName>Université du Havre</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle><tutelle active="#struct-301860" type="direct"><org type="institution" xml:id="struct-301860" status="VALID"> <orgName>CRLCC Henri Becquerel</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle name="IFR23" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="IFR23" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Le Havre</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université du Havre</orgName><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Caraty, Alain" sort="Caraty, Alain" uniqKey="Caraty A" first="Alain" last="Caraty">Alain Caraty</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-199335" status="VALID"> <orgName>Physiologie de la reproduction et des comportements [Nouzilly]</orgName> <orgName type="acronym">PRC</orgName> <desc> <address> <addrLine>Centre de Recherches de Tours 37380 Nouzilly</addrLine> <country key="FR"></country> </address> <ref type="url">http://www6.val-de-loire.inra.fr/physiologie_reproduction_comportements</ref> </desc> <listRelation> <relation active="#struct-300298" type="direct"></relation> <relation name="UR0085" active="#struct-92114" type="direct"></relation> <relation name="UMR7247" active="#struct-441569" type="direct"></relation> <relation active="#struct-200225" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-300298" type="direct"><org type="institution" xml:id="struct-300298" status="VALID"><orgName>Université François Rabelais - Tours</orgName><desc><address><addrLine>60 rue du Plat d'Étain, 37020 Tours cedex 1 </addrLine><country key="FR"></country></address><ref type="url">http://www.univ-tours.fr</ref></desc></org></tutelle><tutelle name="UR0085" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="VALID"> <orgName>Institut National de la Recherche Agronomique</orgName> <orgName type="acronym">INRA</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.inra.fr</ref> </desc></org></tutelle><tutelle name="UMR7247" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle><tutelle active="#struct-200225" type="direct"><org type="institution" xml:id="struct-200225" status="VALID"> <orgName>Institut Français du Cheval et de l'Equitation [Saumur]</orgName> <desc> <address> <addrLine>Terrefort, BP 207, F-49411 Saumur</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ifce.fr/</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Tours</settlement><region type="old region" nuts="2">Région Centre</region><region type="region" nuts="2">Centre-Val de Loire</region></placeName><orgName type="university">Université François-Rabelais de Tours</orgName><orgName type="institution" wicri:auto="newGroup">Centre Val de Loire Université</orgName></affiliation></author><author><name sortKey="Escobar, Sebastian" sort="Escobar, Sebastian" uniqKey="Escobar S" first="Sebastian" last="Escobar">Sebastian Escobar</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-234729" status="INCOMING"> <orgName>Instituto de Acuicultura de Torre de la Sal</orgName> <desc> <address> <addrLine>Torre de la Sal, s/n, Ribera de Cabanes, Castellón, Spain</addrLine> <country key="ES"></country> </address> </desc> <listRelation> <relation active="#struct-302649" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-302649" type="direct"><org type="institution" xml:id="struct-302649" status="VALID"> <orgName>Consejo Superior de Investigaciones Científicas [Spain]</orgName> <orgName type="acronym">CSIC</orgName> <desc> <address> <country key="ES"></country> </address> <ref type="url">http://www.csic.es</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>Espagne</country></affiliation></author><author><name sortKey="Parhar, Ishwar S" sort="Parhar, Ishwar S" uniqKey="Parhar I" first="Ishwar S" last="Parhar">Ishwar S. Parhar</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-31666" status="VALID"> <orgName>Monash University [Malaysia]</orgName> <desc> <address> <addrLine>No. 2 Jalan Universiti, Bandar Sunway, Petaling Jaya - 46150 Selangor Darul Ehsan</addrLine> <country key="MY"></country> </address> </desc></hal:affiliation><country>Malaisie</country></affiliation></author><author><name sortKey="Seong, Jae Yong" sort="Seong, Jae Yong" uniqKey="Seong J" first="Jae Yong" last="Seong">Jae Yong Seong</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-31666" status="VALID"> <orgName>Monash University [Malaysia]</orgName> <desc> <address> <addrLine>No. 2 Jalan Universiti, Bandar Sunway, Petaling Jaya - 46150 Selangor Darul Ehsan</addrLine> <country key="MY"></country> </address> </desc></hal:affiliation><country>Malaisie</country></affiliation></author><author><name sortKey="Vaudry, Hubert" sort="Vaudry, Hubert" uniqKey="Vaudry H" first="Hubert" last="Vaudry">Hubert Vaudry</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1752" status="OLD"> <orgName>IFR multidisciplinaire sur les peptides</orgName> <orgName type="acronym">IMP</orgName> <desc> <address> <addrLine>Place Emile Blondel 76821 Mont Saint Aignan cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-rouen.fr/ifrmp23</ref> </desc> <listRelation> <relation active="#struct-300147" type="direct"></relation> <relation active="#struct-300317" type="direct"></relation> <relation active="#struct-300318" type="direct"></relation> <relation active="#struct-301860" type="direct"></relation> <relation name="IFR23" active="#struct-303623" type="direct"></relation> <relation name="IFR23" active="#struct-441569" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-300147" type="direct"><org type="institution" xml:id="struct-300147" status="VALID"><orgName>CHU Rouen</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300317" type="direct"><org type="institution" xml:id="struct-300317" status="VALID"><orgName>Université du Havre</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle><tutelle active="#struct-301860" type="direct"><org type="institution" xml:id="struct-301860" status="VALID"> <orgName>CRLCC Henri Becquerel</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle name="IFR23" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="IFR23" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Le Havre</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université du Havre</orgName><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Kah, Olivier" sort="Kah, Olivier" uniqKey="Kah O" first="Olivier" last="Kah">Olivier Kah</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-804" status="OLD"> <orgName>Interactions cellulaires et moléculaires</orgName> <orgName type="acronym">ICM</orgName> <desc> <address> <addrLine>bat. 13 et 14 Campus de Beaulieu 35042 RENNES CEDEX</addrLine> <country key="FR"></country> </address> <ref type="url">http://umr6026.univ-rennes1.fr</ref> </desc> <listRelation> <relation active="#struct-105160" type="direct"></relation> <relation active="#struct-300972" type="direct"></relation> <relation name="UMR6026" active="#struct-441569" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName> <orgName type="acronym">UR1</orgName> <desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-rennes1.fr/</ref> </desc></org></tutelle><tutelle active="#struct-300972" type="direct"><org type="institution" xml:id="struct-300972" status="VALID"> <orgName>IFR140</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle name="UMR6026" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rennes</settlement><region type="region" nuts="2">Région Bretagne</region></placeName><orgName type="university">Université de Rennes 1</orgName><orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName></affiliation></author></analytic><idno type="DOI">10.1210/en.2010-0948</idno><series><title level="j">Endocrinology</title><idno type="ISSN">0013-7227</idno><imprint><date type="datePub">2011-04</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Kisspeptins are new actors in the neuroendocrine regulation of reproduction. In vertebrates, the number of kiss genes varies from none to three. Zebrafish have two kiss genes, kiss1 and kiss2, and two kiss receptors (GPR54), kiss1r and kiss2r. To provide detailed information on the organization of the kiss systems in zebrafish, antibodies were raised against the C terminus of zebrafish preproKiss1 and preproKiss2. Immunohistochemistry fully confirmed in situ hybridization data, showing that kiss1-expressing neurons are only located in the habenular nucleus, while kiss2-expressing neurons are found in the dorsal and ventral hypothalamus. Kiss1-expressing cells project only to the interpeduncular and raphe nuclei and strongly expressed the kiss1r receptor. In contrast, kiss2-expressing cells are mostly present in the dorsal and ventral hypothalamus and project widely into the subpallium, the preoptic area, the thalamus, the ventral and caudal hypothalamus, and the mesencephalon. All these regions strongly expressed the kiss2r messengers. Kiss2 fibers profusely innervate the ventral forebrain and notably made close apposition with GnRH3 neurons. Estrogen treatment of juvenile fish with estradiol causes increase in kiss2 and kiss2r expression. In the pituitary gland, no proKiss2- positive fibers were detected, while positive cells were observed in the pars intermedia. In addition to proposing a successful strategy to develop antibodies to kisspeptins, these data indicate that the kiss2 systems of zebrafish are implicated in reproductive events, while the kiss1 gene would play other functions that remain to be established.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>France</li><li>Malaisie</li></country><region><li>Centre-Val de Loire</li><li>Haute-Normandie</li><li>Région Bretagne</li><li>Région Centre</li><li>Région Normandie</li></region><settlement><li>Le Havre</li><li>Rennes</li><li>Rouen</li><li>Tours</li></settlement><orgName><li>Centre Val de Loire Université</li><li>Université François-Rabelais de Tours</li><li>Université de Rennes 1</li><li>Université de Rouen</li><li>Université du Havre</li><li>Université européenne de Bretagne</li></orgName></list><tree><country name="France"><region name="Région Bretagne"><name sortKey="Servili, Arianna" sort="Servili, Arianna" uniqKey="Servili A" first="Arianna" last="Servili">Arianna Servili</name></region><name sortKey="Caraty, Alain" sort="Caraty, Alain" uniqKey="Caraty A" first="Alain" last="Caraty">Alain Caraty</name><name sortKey="Kah, Olivier" sort="Kah, Olivier" uniqKey="Kah O" first="Olivier" last="Kah">Olivier Kah</name><name sortKey="Le Page, Yann" sort="Le Page, Yann" uniqKey="Le Page Y" first="Yann" last="Le Page">Yann Le Page</name><name sortKey="Leprince, Jerome" sort="Leprince, Jerome" uniqKey="Leprince J" first="Jérôme" last="Leprince">Jérôme Leprince</name><name sortKey="Vaudry, Hubert" sort="Vaudry, Hubert" uniqKey="Vaudry H" first="Hubert" last="Vaudry">Hubert Vaudry</name></country><country name="Espagne"><noRegion><name sortKey="Escobar, Sebastian" sort="Escobar, Sebastian" uniqKey="Escobar S" first="Sebastian" last="Escobar">Sebastian Escobar</name></noRegion></country><country name="Malaisie"><noRegion><name sortKey="Parhar, Ishwar S" sort="Parhar, Ishwar S" uniqKey="Parhar I" first="Ishwar S" last="Parhar">Ishwar S. Parhar</name></noRegion><name sortKey="Seong, Jae Yong" sort="Seong, Jae Yong" uniqKey="Seong J" first="Jae Yong" last="Seong">Jae Yong Seong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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